The Single Best Strategy To Use For ceesdekker.net
The Single Best Strategy To Use For ceesdekker.net
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Employing single-molecule optical and AFM imaging and drive-spectroscopy approaches, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our exploration passions consist of:
You regularly get entangled in discussions about science and religion. You've got also written various publications on the topic. Don’t you imagine that at some point We are going to know every thing Which God’s part will be in excess of?
Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I
Non-equilibrium folding of personal DNA molecules recaptured around 1000 occasions inside a strong state nanopore
We produce level-of-care diagnostics exam of neglected tropical disorders in source-restricted configurations, determined by Crspr/Cas9 detecting of pathogen’s DNA in entire body fluids.
In the many years following these discoveries, my investigate pursuits shifted to biophysics and nanobiology, and I became much less involved in the event of nanotube electronics. The main focus of many scientists in the sector also shifted to graphene (exactly where, funnily sufficient, the first graphene ribbons were being referred to as ‘nanotubes which can be Reduce open up alongside their size’) following the invention of the two-dimensional content in 2004.
We condition micro organism into varieties that deviate from their normal phenotype. Especially, I will show our power to form Dwell E. coli germs into novel shapes which include rectangles, squares, triangles and circles.
2000, discovery that nanotubes can have extraordinary massive present-day densities; settled the controversial challenge of electronic transport by DNA molecules by measurements of insulating behavior at the single molecule stage; and demonstration of the AFM method for solitary-molecule manipulation of nanotubes
‘You should not just https://www.ceesdekker.net think of the inquiries of tomorrow, and also evaluate the questions of the working day just after tomorrow’
‘The fantastically refined way where aspects in character perform in no way ceases to amaze me. If we resolve the puzzle of how life arrived into currently being, I assume that my amazement in the complexity of creation should have enhanced and with it my awe to the greatness from the Creator.’
Since 2000 he moved to solitary-molecule biophysics and nanobiology, with study from experiments of DNA loop extrusion and supercoiling to DNA translocation by nanopores. Much more a short while ago his investigation has focused on finding out chromatin structure and cell division with bacteria on chip, even though he can also be aiming to ultimately Make synthetic cells from the bottom up.
Cees Dekker is Distinguished University Professor at TU Delft. Skilled like a physicist, he pioneered nanotechnology with several discoveries on carbon nanotubes while in the nineties. Considering that 2000, he moved to solitary-molecule biophysics and nanobiology. His existing analysis focuses on (i) nanopores for protein sequencing; (ii) chromosome construction, in particular SMC motor protein; and (iii) building a dwelling artificial mobile from lifeless molecules. Dekker is really an elected member on the KNAW and fellow on the APS along with the IOP.
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Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim on the pore is highlighted in red, plus a 3D rendering from the movement of the DNA rod is shown.